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Peptide Radioligands

Radioligands are often attached to the Nterminus of peptides, also can be attached to the internal or C-terminus via inserted a lysine. Examples include the attachment of DTPA, DOTA, DOPA, NOTA, NODAGA, HYNIC etc...

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DTPA

Diethylenetriaminepentaacetic acid (DTPA) is a useful chelating agent for radionuclides such as (68)Ga, (99m)Tc and (111)In, which are applicable to nuclear medicine imaging.

DOTA

Metal complexes of DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid)-peptide conjugates are increasingly used as targeted imaging and therapeutic radiopharmaceuticals and MRI contrast agents.

DTPA
DOTA
NOTA
NODAGA
HYNIC