Hello! Welcome to ONTORES!

CN +86-21-68388652

Your shopping cart is empty.

According to the order.

Ordering Center

Contact us

  • Email: sales@ontores.com
  • Tel: +86-21-6838 8652
  • Fax: +86-21-6838 8639

N Terminal Modifications

Peptides can be modified at the N terminus. In general, some standard peptide moieties must be accessible in order to be modified: an N-terminal amino group, the amino group of Lys, the thiol group of Cys, the hydroxyl groups of Ser, Thr, and Tyr, the guanidine group of Arg, and the C-terminal carboxyl group.

N-terminal modification reduces overall solubility of the peptide by reducing its overall charges. However, the stability of the peptide could also be increased because N terminal modification generates a closer mimic of the native protein. Therefore, these modifications might increase the biological activity of a peptide and prevent degradation by enzymes.

Get a quote
N Terminus Modification Structure

Bz

Benzoyl

Br-Ac

Bromoacetyl

CBZ

Benzyloxycarbonylation

DL-Lipoic acid

Fmoc

9-Fluorenylmethyloxycarbonyl

For

Formylation

HPP

4-Hydroxyphenylpropionic acid

MCA

6-Maleimidohexanoic acid

Maleimide

Mpa

3-Mercaptopropyl

Myristic acid

Succinylation

Thioester

Boc

Tertbutoxycarbonyl